Intermittent blood flow in a murine tumor: radiobiological effects.

  title={Intermittent blood flow in a murine tumor: radiobiological effects.},
  author={D J Chaplin and Peggy L. Olive and Ralph E. Durand},
  journal={Cancer research},
  volume={47 2},
Little is known about how and why hypoxia arises in tumors, i.e., whether hypoxia is a chronic process resulting from diffusion limitations or occurs more acutely due to transient changes in blood perfusion. We have investigated the nature of hypoxia in the murine squamous carcinoma SCC VII using a new fluorescence-activated cell-sorting technique which facilitates isolation of viable tumor cells as a function of their distance from the blood supply. The technique utilizes the DNA binding… CONTINUE READING

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