Intermittent administration of human parathyroid hormone (1-34) increases new bone formation on the interface of hydroxyapatitecoated titanium rods implanted into ovariectomized rat femora.

@article{Ohkawa2008IntermittentAO,
  title={Intermittent administration of human parathyroid hormone (1-34) increases new bone formation on the interface of hydroxyapatitecoated titanium rods implanted into ovariectomized rat femora.},
  author={Yutaka Ohkawa and Kunihiko Tokunaga and Naoto Endo},
  journal={Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association},
  year={2008},
  volume={13 6},
  pages={533-42}
}
BACKGROUND As hydroxyapatite (HA) has good osteoconductive properties, HA is used as coating material for the implants in cementless arthroplasty. However, its effect is not sufficient for osteoporotic bone. Parathyroid hormone (PTH) is known to have anabolic effects on bone formation. Intermittent administration of PTH increases both cancellous and cortical bone mass. The aim of this study was to confirm the effect of the fixation strength of HA-coated implants in the osteoporotic condition… CONTINUE READING

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