Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity.

@article{Nankabirwa2016IntermittentPT,
  title={Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity.},
  author={Joaniter Nankabirwa and Melissa D. Conrad and Jennifer Legac and Stephen Tukwasibwe and Patrick K Tumwebaze and Bonnie Wandera and Simon J. Brooker and Sarah G. Staedke and Moses R. Kamya and Sam L. Nsobya and Grant Dorsey and Philip J. Rosenthal},
  journal={Antimicrobial agents and chemotherapy},
  year={2016},
  volume={60 10},
  pages={
          5649-54
        }
}
Dihydroartemisinin-piperaquine (DP) offers prolonged protection against malaria, but its impact on Plasmodium falciparum drug sensitivity is uncertain. In a trial of intermittent preventive treatment in schoolchildren in Tororo, Uganda, in 2011 to 2012, monthly DP for 1 year decreased the incidence of malaria by 96% compared to placebo; DP once per school term offered protection primarily during the first month after therapy. To assess the impact of DP on selection of drug resistance, we… CONTINUE READING
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