Intermittent PTH administration and mechanical loading are anabolic for periprosthetic cancellous bone.

@article{Grosso2015IntermittentPA,
  title={Intermittent PTH administration and mechanical loading are anabolic for periprosthetic cancellous bone.},
  author={Matthew J. Grosso and Hayden-William Courtland and Xu Yang and James P Sutherland and Kirsten Stoner and Joseph An Nguyen and Anna Fahlgren and Frederick Ross and Marjolein C H van der Meulen and Mathias P. G. Bostrom},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2015},
  volume={33 2},
  pages={163-73}
}
The purpose of this study was to determine the individual and combined effects on periprosthetic cancellous bone of intermittent parathyroid hormone administration (iPTH) and mechanical loading at the cellular, molecular, and tissue levels. Porous titanium implants were inserted bilaterally on the cancellous bone of adult rabbits beneath a loading device attached to the distal lateral femur. The left femur received a sham loading device. The right femur was loaded daily, and half of the rabbits… CONTINUE READING
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