Intermedin elicits a negative inotropic effect in rat papillary muscles mediated by endothelial-derived nitric oxide.

Abstract

Intermedin (IMD) is a novel vasoactive peptide from the calcitonin gene-related peptide (CGRP) implicated in cardiac regulation, yet the contractile effects of IMD remain controversial, since previous studies in vivo and isolated cardiomyocytes documented contradictory results. We hypothesized cardiac endothelial cells involvement in IMD modulation of… (More)
DOI: 10.1152/ajpheart.00877.2011

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