Intermedin (adrenomedullin2) stabilizes the endothelial barrier and antagonizes thrombin-induced barrier failure in endothelial cell monolayers.

@article{Aslam2012IntermedinS,
  title={Intermedin (adrenomedullin2) stabilizes the endothelial barrier and antagonizes thrombin-induced barrier failure in endothelial cell monolayers.},
  author={Muhammad Javaid Aslam and Uwe Pfeil and Dursun Guenduez and Amir Rafiq and Wolfgang Kummer and Hans Michael Piper and Thomas Noll},
  journal={British journal of pharmacology},
  year={2012},
  volume={165 1},
  pages={208-22}
}
BACKGROUND AND PURPOSE Intermedin is a member of the calcitonin gene-related-peptide (CGRP) family expressed in endothelial cells and acts via calcitonin receptor-like receptors (CLRs). Here we have analysed the receptors for intermedin and its effect on the endothelial barrier in monolayers of human umbilical vein endothelial cells (HUVECs). EXPERIMENTAL APPROACH We analysed the effect of intermedin on albumin permeability, contractile machinery, actin cytoskeleton and VE-cadherin in… CONTINUE READING
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