Intermediates and kinetics of membrane fusion.

  title={Intermediates and kinetics of membrane fusion.},
  author={Joe Bentz},
  journal={Biophysical journal},
  volume={63 2},
  • Joe Bentz
  • Published 1992 in Biophysical journal
Recently, it has become clear that the influenza virus fusion protein, hemagglutinin (HA), produces membrane destabilization and fusion by a multistep process, which involves the aggregation of the HAs to form a fusion site. While the details of this process are under debate, it is important to recognize that proposing any sequence of "microscopic" fusion intermediates encumbers general "macroscopic" kinetic consequences, i.e., with respect to membrane mixing rates. Using a kinetic scheme which… CONTINUE READING

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