Intermediate-term processes in memory formation

  title={Intermediate-term processes in memory formation},
  author={Shara Stough and Justin L. Shobe and Thomas J. Carew},
  journal={Current Opinion in Neurobiology},
The Making of Long-Lasting Memories: A Fruit Fly Perspective
Recent literature regarding how the formation of memories induces a rapid, extensive and, in many cases, transient wave of transcriptional activity is reviewed.
Transcriptional regulation of long-term potentiation
Identification of all the proteins and non-coding RNA transcripts expressed during LTP may provide greater insight into the molecular mechanisms involved in learning and memory formation.
Massed Training-Induced Intermediate-Term Operant Memory in Aplysia Requires Protein Synthesis and Multiple Persistent Kinase Cascades
It is found that massed LFI training resulted in temporally distinct protein synthesis-dependent memory evident 4–6 h after training, and sustained MAPK phosphorylation was dependent upon protein synthesis, but not PKA or PKC activity.
Transcriptional Mechanisms Involved in Long-term Potentiation of Hippocampal Neurons
This project aimed to investigate the transcriptomic changes that result from inhibition of LTP through disruption of synaptic adhesion, and characterisation of all the proteins and lncRNAs involved in LTP may elucidate the molecular mechanisms underlying memory formation and consolidation as well as provide greater insight into perturbation of these processes in developmental and neurodegenerative diseases.
Parallel processing of olfactory memories in Drosophila
Using an aversive olfactory conditioning task in Drosophila, it is found that cAMP signaling in different neuron cell types is sufficient to support short or long-term memory independently.


Intermediate-Term Memory for Site-Specific Sensitization in Aplysia Is Maintained by Persistent Activation of Protein Kinase C
It is shown that a single tail shock can also induce ITM that is expressed selectively at the trained site (site-specific ITM), which is phenotypically similar to the form of ITM induced by repeated trials, but the mechanisms by which site- specific ITM is induced and maintained are distinct.
Dynamics of Induction and Expression of Long-Term Synaptic Facilitation in Aplysia
The hypothesis that LTF is not a simple elaboration of STF is supported, raising the possibility that STF, ITF, and LTF may reflect components of different memory phases in the intact animal.
Interaction between amount and pattern of training in the induction of intermediate- and long-term memory for sensitization in aplysia.
The results indicate that in addition to three identified phases of memory for sensitization--STM, ITM, and LTM--a unique temporal profile of memory, E-ITM, is revealed by varying either the amount or pattern of training.
Dynamic memory networks: dissecting molecular mechanisms underlying associative memory in the temporal domain.
The temporal features of molecular processes in learning and memory formation are focused on, recent knowledge is summarized, current knowledge is presented and an outlook on future developments is presented.
A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia.
The results parallel those for behavioral performance in vertebrates and indicate that the critical time window characteristic of the requirement for macromolecular synthesis in long-term heterosynaptic facilitation is not a property of complex circuitry, but an intrinsic characteristic of specific nerve cells and synaptic connections involved in the long- term storage of information.
Induction of long-term facilitation in Aplysia sensory neurons by local application of serotonin to remote synapses.
  • G. A. Clark, E. Kandel
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1993
This work has explored a set of remote, peripheral terminals of siphon sensory cells, which are approximately 3 cm from the sensory cell body in the abdominal ganglion, and found that these remote synapses, like the proximal synapses previously studied in dissociated cell culture, can exhibit long-term facilitation 24 hr after cell-wide serotonin application.