Intermediate sequences increase the detection of homology between sequences.

@article{Park1997IntermediateSI,
  title={Intermediate sequences increase the detection of homology between sequences.},
  author={J Park and Sarah A. Teichmann and Tim Hubbard and Cyrus Chothia},
  journal={Journal of molecular biology},
  year={1997},
  volume={273 1},
  pages={
          349-54
        }
}
Two homologous sequences, which have diverged beyond the point where their homology can be recognised by a simple direct comparison, can be related through a third sequence that is suitably intermediate between the two. High scores, for a sequence match between the first and third sequences and between the second and the third sequences, imply that the first and second sequences are related even though their own match score is low. We have tested the usefulness of this idea using a database… CONTINUE READING

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