Intermediate filaments mediate cytoskeletal crosstalk

@article{Chang2004IntermediateFM,
  title={Intermediate filaments mediate cytoskeletal crosstalk},
  author={Lynne Chang and Robert D. Goldman},
  journal={Nature Reviews Molecular Cell Biology},
  year={2004},
  volume={5},
  pages={601-613}
}
Intermediate filaments, actin-containing microfilaments and microtubules are the three main cytoskeletal systems of vertebrate and many invertebrate cells. Although these systems are composed of distinctly different proteins, they are in constant and intimate communication with one another. Understanding the molecular basis of this cytoskeletal crosstalk is essential for determining the mechanisms that underlie many cell-biological phenomena. Recent studies have revealed that intermediate… Expand
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Intermediate Filaments as Signaling Platforms
TLDR
A wide range of previously unknown nonmechanical roles for the IF cytoskeleton are emerging, including the integration of signals related to the determination of cell size, the regulation of cell migration and cell survival, and the buffering of the effects of stress-activated kinases. Expand
Intermediate filaments: a dynamic network that controls cell mechanics
TLDR
The role of nuclear IF organization in determining nuclear mechanics as well as that of cytoplasmic IFs organization in maintaining cell stiffness, formation of lamellipodia, regulation of cell migration, and permitting cell adhesion is discussed. Expand
Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling
TLDR
Current knowledge on how the crosstalk between IFs and actin filaments modulates the migration properties, mechano-responsiveness and signaling transduction of cells is recapitulates from both biophysical and biochemical point of view. Expand
Cytoskeletal crosstalk: when three different personalities team up.
TLDR
There is growing evidence that the three cytoskeletal subsystems also exhibit strongly coupled functions necessary for polarization, cell migration, and mechano-responsiveness, and this evidence is summarized from a biophysical point of view. Expand
Cytoskeletal Interactions in the Neuron
TLDR
The discovery of new plakin genes and alternative splice isoforms has made it clear that plakins can associate with multiple cytoskeletal filaments, and this work aims to clarify the function of these proteins. Expand
The motility and dynamic properties of intermediate filaments and their constituent proteins.
TLDR
The recent findings that IF and their precursors are frequently associated with signaling molecules have revealed new functions for IF beyond their more traditional roles as mechanical integrators of cells and tissues. Expand
Intermediate Filaments and Vesicular Membrane Traffic: The Odd Couple's First Dance?
TLDR
Evidence suggesting that intermediate filaments may play roles in controlling organelle positioning and in membrane protein targeting is discussed and potential mechanisms by which IFs may regulate the localization and function of organelles are discussed. Expand
Vimentin Intermediate Filaments Stabilize Dynamic Microtubules by Direct Interactions
TLDR
An additional, direct mechanism for cells to establish the fundamental cross-talk of cytoskeletal components alongside linker proteins is described and a novel strategy to estimate the binding energy of tubulin dimers within the microtubule lattice is suggested. Expand
The vimentin cytoskeleton: When polymer physics meets cell biology.
TLDR
This review highlights exciting new results on the physical biology of vimentin intermediate filaments and their role in allowing whole cells and tissues to cope with stress. Expand
Nucleotide‐independent cytoskeletal scaffolds in bacteria
TLDR
The elements that constitute the nucleotide‐independent cytoskeleton of bacteria are highlighted and their biological functions in different species are discussed. Expand
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References

SHOWING 1-10 OF 142 REFERENCES
Intermediate filament assembly: fibrillogenesis is driven by decisive dimer-dimer interactions.
TLDR
The key question of how these filaments assemble and what the molecular architecture of their distinct assembly intermediates comprises has still not been answered to the extent that has been achieved for microfilaments and microtubules. Expand
Plakins: a family of versatile cytolinker proteins.
TLDR
The members of the plakin family and their interaction partners are described, and examples of the cellular defects that result from their dysfunction are given. Expand
Phosphorylation and reorganization of vimentin by p21‐activated kinase (PAK)
TLDR
The Rho family of small GTPases, such as Cdc42, Rac and Rho, are thought to control the organization of actin filaments as well as other cytoskeletal filaments. Expand
Intermediate filaments regulate astrocyte motility
TLDR
It is shown that reactive astrocytes devoid of IFs exhibit clear morphological changes and profound defects in cell motility thereby revealing a novel function for IFs. Expand
The dynamic and motile properties of intermediate filaments.
TLDR
This review considers the functional implications of the motile properties of IFs and discusses the potential relationships between malfunctions in these motile activities and human diseases. Expand
Transmembrane crosstalk between the extracellular matrix and the cytoskeleton
TLDR
This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces. Expand
De novo formation of cytokeratin filament networks originates from the cell cortex in A-431 cells.
TLDR
It is demonstrated that filament formation is initiated from the cell cortex without focal preference after cytokinesis, and it is shown that this process is dependent on energy, on the integrity of the actin filament network and the microtubule system, and that it can be inhibited by the tyrosine phosphatase inhibitor pervanadate. Expand
Rho GTPases in cell biology
TLDR
Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant. Expand
The function of intermediate filaments in cell shape and cytoskeletal integrity
TLDR
The results demonstrate that at 1:1 molar ratios, mimetic peptides derived from the amino acid sequence of the helix initiation 1A domain of IF protein chains disassemble vimentin IF into small oligomeric complexes and monomers within 30 min at room temperature in vitro. Expand
Cytoskeletal integrity in interphase cells requires protein phosphatase activity.
TLDR
The results indicate that there is a rapid phosphate turnover on cytoskeletal intermediate filaments and suggest that protein phosphatases are essential for the maintenance and structural integrity of two major cytOSkeletal components. Expand
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