Intermediate filaments enable pathogen docking to trigger type 3 effector translocation

@inproceedings{Russo2016IntermediateFE,
  title={Intermediate filaments enable pathogen docking to trigger type 3 effector translocation},
  author={Brian C. Russo and Luisa M. Stamm and Matthijs Raaben and Caleb M Kim and Emily Rose Kahoud and Lindsey Rose Robinson and Sayantan Bose and Ana L{\'u}cia Queiroz and Bobby Brooke Herrera and Leigh A. Baxt and Nirit Mor-Vaknin and Yang Fu and Gabriel Molina and David M Markovitz and Sean P J Whelan and Marcia B. Goldberg},
  booktitle={Nature Microbiology},
  year={2016}
}
Type 3 secretion systems (T3SSs) of bacterial pathogens translocate bacterial effector proteins that mediate disease into the eukaryotic cytosol. Effectors traverse the plasma membrane through a translocon pore formed by T3SS proteins. In a genome-wide selection, we identified the intermediate filament vimentin as required for infection by the T3SS-dependent pathogen S. flexneri. We found that vimentin is required for efficient T3SS translocation of effectors by S. flexneri and other pathogens… CONTINUE READING
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