Intermediate filaments as differentiation markers of exocrine pancreas. II. Expression of cytokeratins of complex and stratified epithelia in normal pancreas and in pancreas cancer.

@article{Real1993IntermediateFA,
  title={Intermediate filaments as differentiation markers of exocrine pancreas. II. Expression of cytokeratins of complex and stratified epithelia in normal pancreas and in pancreas cancer.},
  author={Francisco X Real and Maya R. Vil{\`a} and Anouchka Skoudy and Frans C. S. Ramaekers and Josep Mar{\'i}a Corominas},
  journal={International journal of cancer},
  year={1993},
  volume={54 5},
  pages={
          720-7
        }
}
Cytokeratin (CK) expression in tumors generally reflects the CK pattern of the corresponding normal epithelium. Pancreas cancers express CK of simple epithelia 7, 8, 18 and 19, as normal ductal cells. To analyze whether CK of complex or stratified epithelia are abnormally expressed in pancreas cancers, we have used polypeptide-specific mouse monoclonal antibodies (MAbs) detecting CK 5, CK 10, CK 13, CK 14 and CK 17, and an antibody detecting CK 13, CK 15 and CK 16. The streptavidin-peroxidase… CONTINUE READING

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