Intermediate filaments: from cell architecture to nanomechanics

  title={Intermediate filaments: from cell architecture to nanomechanics},
  author={Harald Herrmann and Harald B{\"a}r and Laurent Kreplak and Sergei V. Strelkov and Ueli Aebi},
  journal={Nature Reviews Molecular Cell Biology},
Intermediate filaments (IFs) constitute a major structural element of animal cells. They build two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major function is assumed to be that of a mechanical stress absorber and an integrating device for the entire cytoskeleton. In line with this, recent disease mutations in human IF proteins indicate that the nanomechanical properties of cell-type-specific IFs are central to the pathogenesis of diseases as diverse as… 

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  • L. KreplakD. Fudge
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2007
Electron microscopy data suggest that IFs are built according to a completely different plan from that of MFs and MTs, which has important implications for the understanding of cell and tissue mechanics.

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