Intermediate filaments: from cell architecture to nanomechanics

  title={Intermediate filaments: from cell architecture to nanomechanics},
  author={H. Herrmann and H. B{\"a}r and L. Kreplak and S. Strelkov and U. Aebi},
  journal={Nature Reviews Molecular Cell Biology},
  • H. Herrmann, H. Bär, +2 authors U. Aebi
  • Published 2007
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • Intermediate filaments (IFs) constitute a major structural element of animal cells. They build two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major function is assumed to be that of a mechanical stress absorber and an integrating device for the entire cytoskeleton. In line with this, recent disease mutations in human IF proteins indicate that the nanomechanical properties of cell-type-specific IFs are central to the pathogenesis of diseases as diverse as… CONTINUE READING
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