Intermediate filaments: from cell architecture to nanomechanics

@article{Herrmann2007IntermediateFF,
  title={Intermediate filaments: from cell architecture to nanomechanics},
  author={Harald Herrmann and Harald B{\"a}r and Laurent Kreplak and Sergei V. Strelkov and Ueli Aebi},
  journal={Nature Reviews Molecular Cell Biology},
  year={2007},
  volume={8},
  pages={562-573}
}
Intermediate filaments (IFs) constitute a major structural element of animal cells. They build two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major function is assumed to be that of a mechanical stress absorber and an integrating device for the entire cytoskeleton. In line with this, recent disease mutations in human IF proteins indicate that the nanomechanical properties of cell-type-specific IFs are central to the pathogenesis of diseases as diverse as… Expand
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TLDR
The atomic structure of this elementary dimer, elucidated using X-ray crystallography on multiple fragments and electron paramagnetic resonance experiments on spin-labelled vimentin samples, shows that the rod of all IF proteins is composed of three coiled-coil segments containing heptad and hendecad repeats and interconnected by linkers. Expand
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