Intermediate filament transcription in astrocytes is repressed by proteasome inhibition.

  title={Intermediate filament transcription in astrocytes is repressed by proteasome inhibition.},
  author={Jinte Middeldorp and Willem Kamphuis and Jacqueline A. Sluijs and Dalila Achoui and Cathalijn H C Leenaars and M. Feenstra and Paula van Tijn and David F. Fischer and Celia R Berkers and Huib Ovaa and Roy A Quinlan and Elly M. Hol},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={23 8},
Increased expression of the astrocytic intermediate filament protein glial fibrillary acidic protein (GFAP) is a characteristic of astrogliosis. This process occurs in the brain during aging and neurodegeneration and coincides with impairment of the ubiquitin proteasome system. Inhibition of the proteasome impairs protein degradation; therefore, we hypothesized that the increase in GFAP may be the result of impaired proteasomal activity in astrocytes. We investigated the effect of proteasome… CONTINUE READING


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