Intermediate filament proteins of digestive organs: physiology and pathophysiology.

  title={Intermediate filament proteins of digestive organs: physiology and pathophysiology.},
  author={M. Bishr Omary},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={312 6},
Intermediate filament proteins (IFs), such as cytoplasmic keratins in epithelial cells and vimentin in mesenchymal cells and the nuclear lamins, make up one of the three major cytoskeletal protein families. Whether in digestive organs or other tissues, IFs share several unique features including stress-inducible overexpression, abundance, cell-selective and differentiation state expression, and association with >80 human diseases when mutated. Whereas most IF mutations cause disease, mutations… CONTINUE READING