Intermediate doses of melphalan and dexamethasone are better than vincristine, adriamycin, and dexamethasone (VAD) and polychemotherapy for the treatment of primary plasma cell leukemia

@article{VelaOjeda2002IntermediateDO,
  title={Intermediate doses of melphalan and dexamethasone are better than vincristine, adriamycin, and dexamethasone (VAD) and polychemotherapy for the treatment of primary plasma cell leukemia},
  author={Jorge Vela-Ojeda and Miriam Garc{\'i}a-Ruiz Esparza and Alejandro Rosas-Cabral and Ysabel Padilla-Gonz{\'a}lez and Jaime Garc{\'i}a-Ch{\'a}vez and Francisco Tripp-Villanueva and Evelia S{\'a}nchez-Cort{\'e}s and Manuel Ayala-S{\'a}nchez and L. D. Garc{\'i}a-Le{\'o}n and Laura Arcelia Montiel-Cervantes and M E Rubio-Borja},
  journal={Annals of Hematology},
  year={2002},
  volume={81},
  pages={362-367}
}
Primary plasma cell leukemia (PPCL) is a rare form of disease accounting for 1–2% of myelomas. Between September 1990 and November 2000, among 540 patients with myeloma studied, 24 fulfilled the criteria of PPCL (4.4%). We found high frequencies of female patients (62%), Bence Jones proteinuria (79%), anemia (88%), bleeding (54%), confusional syndrome (42%), weight loss (71%), hepatomegaly (25%), splenomegaly (21%), leukocytosis (62%), and thrombocytopenia (71%). High serum levels of creatinine… CONTINUE READING

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Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 10 references

solidation therapy with autologous stem cell transplantation in plasma cell leukemia after VAD , high - dose cyclophosphamide and EDAP courses : a report of three cases and a review of the literature

S Hovenga, Wolf JThM, H Klip, E Vellenga
Bone Marrow Transplant • 1997

[Primary plasma cell leukemia--a comprehensive analysis of 44 cases].

Zhonghua zhong liu za zhi [Chinese journal of oncology] • 1990

Plasma cell leukemia.

Seminars in hematology • 1987

Plas - ma cell leukemia ( PCL ) : a report on 15 patients

RK Woodruff, JS Malpas, AM Pastón, TA Lister
Blood • 1978

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