Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor.

Abstract

The molecular mechanism underlying channel opening in response to agonist binding remains a challenging issue in neuroscience. In this regard, many efforts have been recently undertaken in ATP-gated P2X receptors. Among those efforts, we have provided evidence in the P2X2 receptor that tightening of ATP sites upon agonist binding induces opening of the ion… (More)
DOI: 10.4161/chan.21520

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