Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor.


The molecular mechanism underlying channel opening in response to agonist binding remains a challenging issue in neuroscience. In this regard, many efforts have been recently undertaken in ATP-gated P2X receptors. Among those efforts, we have provided evidence in the P2X2 receptor that tightening of ATP sites upon agonist binding induces opening of the ion… (More)
DOI: 10.4161/chan.21520


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics