Intermediate and long-term memory are different at the neuronal level in Lymnaea stagnalis (L.)

@article{Braun2011IntermediateAL,
  title={Intermediate and long-term memory are different at the neuronal level in Lymnaea stagnalis (L.)},
  author={Marvin H. Braun and Ken Lukowiak},
  journal={Neurobiology of Learning and Memory},
  year={2011},
  volume={96},
  pages={403-416}
}
View on Elsevier
doi.org
33 Citations
Highly Influential Citations
2
Background Citations
19
Methods Citations
4
Results Citations
4

33 Citations

Differences in neuronal activity explain differences in memory forming abilities of different populations of Lymnaea stagnalis
Involvement of Insulin-Like Peptide in Long-Term Synaptic Plasticity and Long-Term Memory of the Pond Snail Lymnaea stagnalis
TLDR
The data suggest that MIPs trigger changes in synaptic connectivity that may be correlated with the consolidation of taste aversion learning into CTA–LTM in the Lymnaea CNS.
Inverse Relationship between Basal Pacemaker Neuron Activity and Aversive Long-Term Memory Formation in Lymnaea stagnalis
TLDR
The first evidence suggesting that lower neuronal activity at the time of learning may be correlated with better memory formation in spontaneously active neurons is provided, providing new insights into the diversity of cellular rules of plasticity underlying memory formation.
The effect of rearing environment on memory formation
TLDR
Two lab-bred strains of Lymnaea stagnalis, derived from the same original population, demonstrate a difference in memory-forming ability, possibly due to environmental factors.
How Stress Alters Memory in ‘Smart’ Snails
TLDR
Despite the two populations with enhanced memory formation originating from different continents, LTM formation was indistinguishable in both control and stressed conditions, indicating that the underlying mechanisms controlling cognitive differences among populations may be highly conserved in L. stagnalis.
Strain-specific differences of the effects of stress on memory in Lymnaea
TLDR
It is shown that the same stressor has significantly different effects on memory formation depending on whether snails are ‘smart’ or ‘average’, and it is suggested that a stressor or a combination of stressors act to enhance memory in “average” snails but obstruct memory formation in ‘ smart’ snails.
Sensory input from the osphradium modulates the response to memory-enhancing stressors in Lymnaea stagnalis
TLDR
Sensory input from the osphradium is necessary for LTM enhancement following exposure to these chemical stressors, and no response is seen in RPeD1 in osphradially cut animals.
Juveniles of Lymnaea ‘smart’ snails do not perseverate and have the capacity to form LTM
TLDR
It is shown that juveniles of two smart snail strains not only are capable of associative learning but also have the capacity to form LTM following a single 0.5 h training session; ‘average’ juvenile snails do not possess this ability.
A flavonoid, quercetin, is capable of enhancing long-term memory formation if encountered at different times in the learning, memory formation, and memory recall continuum.
TLDR
The present study provides the first support for Q-modulated enhancement of cognitive function in an invertebrate model, the pond snail Lymnaea stagnalis, after an operant conditioning procedure.
Operant Conditioning of Respiration in Lymnaea: The Environmental Context
...
...

References

SHOWING 1-10 OF 57 REFERENCES
Boosting intermediate-term into long-term memory
TLDR
Data support the concept that a molecular memory trace is established as a consequence of ITM-training, which serves as a `permissive substrate', when the ITM memory is made active, sufficient to permit the necessary transcription and translation processes that are causal for LTM formation.
Intermediate and long-term memories of associative learning are differentially affected by transcription versus translation blockers inLymnaea
TLDR
In Lymnaea, following associative learning, both ITM and LTM are dependent on new protein synthesis, whereas ITM appears to be dependent on protein synthesis from preexisting transcription factors, whilst LTM is dependent onprotein synthesis from new transcription messages.
A molluscan model system in the search for the engram
Reconsolidation of a Long-Term Memory in Lymnaea Requires New Protein and RNA Synthesis and the Soma of Right Pedal Dorsal 1
TLDR
The data indicate that reconsolidation requires both new RNA and protein synthesis to stabilize a reactivated memory, and it demonstrates that the soma of RPeD1, a cell that has been shown previously to be required in the consolidation of an LTM, is necessary for reconsolidations.
Memory, reconsolidation and extinction in Lymnaea require the soma of RPeD1.
TLDR
This work uses an operant conditioning training procedure that results in a long-term non-declarative memory (LTM) and shows that RPeD1 is a necessary site for LTM formation, the first time a single neuron has been shown to be a necessary sites for these different aspects memory.
Enhancing memory formation by altering protein phosphorylation balance
Low environmental calcium blocks long-term memory formation in a freshwater pulmonate snail
Operant conditioning in Lymnaea: evidence for intermediate- and long-term memory.
TLDR
Training using procedures that varied in the duration of the training session, the number of training sessions per day or the amount of time between subsequent training sessions found that by varying the duration and frequency of theTraining session learning could be differentially produced.
The Soma of RPeD1 must be present for long-term memory formation of associative learning in Lymnaea.
TLDR
If RPeD1's soma is ablated after LTM consolidation has occurred, LTM can still be accessed, and thus the soma of R PeD1 is a site of LTM formation.
The participation of NMDA receptors, PKC, and MAPK in the formation of memory following operant conditioning in Lymnaea
TLDR
It is found that NMDA receptor activity was necessary in order for both ITM and LTM formation, and the injection of either U0126 or GF109203X, which inhibit MAPK and PKC activity respectively, 1 hour prior to training results in the inhibition of both ITm and L TM formation.
...
...