Intermediate-Term Graft Loss After Renal Transplantation is Associated With Both Donor-Specific Antibody and Acute Rejection

@article{Devos2014IntermediateTermGL,
  title={Intermediate-Term Graft Loss After Renal Transplantation is Associated With Both Donor-Specific Antibody and Acute Rejection},
  author={Jennifer M Devos and A Osama Gaber and Larry D. Teeter and Edward A. Graviss and Samir J. Patel and Geoffrey A. Land and Linda W Moore and Richard J Knight},
  journal={Transplantation},
  year={2014},
  volume={97 5},
  pages={534-40}
}
BACKGROUND Renal transplant recipients with de novo DSA (dDSA) experience higher rates of rejection and worse graft survival than dDSA-free recipients. This study presents a single-center review of dDSA monitoring in a large, multi-ethnic cohort of renal transplant recipients. METHODS The authors performed a nested case-control study of adult kidney and kidney-pancreas recipients from July 2007 through July 2011. Cases were defined as dDSA-positive whereas controls were all DSA-negative… CONTINUE READING

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