Intermediate Filaments Play a Pivotal Role in Regulating Cell Architecture and Function*

  title={Intermediate Filaments Play a Pivotal Role in Regulating Cell Architecture and Function*},
  author={J. Lowery and E. Kuczmarski and H. Herrmann and R. Goldman},
  journal={The Journal of Biological Chemistry},
  pages={17145 - 17153}
  • J. Lowery, E. Kuczmarski, +1 author R. Goldman
  • Published 2015
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Intermediate filaments (IFs) are composed of one or more members of a large family of cytoskeletal proteins, whose expression is cell- and tissue type-specific. Their importance in regulating the physiological properties of cells is becoming widely recognized in functions ranging from cell motility to signal transduction. IF proteins assemble into nanoscale biopolymers with unique strain-hardening properties that are related to their roles in regulating the mechanical integrity of cells… CONTINUE READING
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