Intermediate-Conductance-Ca2-Activated K Channel IKCa1 Is Upregulated and Promotes Cell Proliferation in Cervical Cancer

@article{Liu2017IntermediateConductanceCa2ActivatedKC,
  title={Intermediate-Conductance-Ca2-Activated K Channel IKCa1 Is Upregulated and Promotes Cell Proliferation in Cervical Cancer},
  author={Ling Liu and Ping Zhan and Dan Nie and Lingye Fan and Hairui Lin and Lanyang Gao and Xiguang Mao},
  journal={Medical science monitor basic research},
  year={2017},
  volume={23},
  pages={
          45-57
        }
}
BACKGROUND Accumulating data point to intermediate-conductance calcium-activated potassium channel (IKCa1) as a key player in controlling cell cycle progression and proliferation of human cancer cells. However, the role that IKCa1 plays in the growth of human cervical cancer cells is largely unexplored. MATERIAL AND METHODS In this study, Western blot analysis, immunohistochemical staining, and RT-PCR were first used for IKCa1protein and gene expression assays in cervical cancer tissues and… CONTINUE READING