Interlocus gene conversion events introduce deleterious mutations into at least 1% of human genes associated with inherited disease.

Abstract

Establishing the molecular basis of DNA mutations that cause inherited disease is of fundamental importance to understanding the origin, nature, and clinical sequelae of genetic disorders in humans. The majority of disease-associated mutations constitute single-base substitutions and short deletions and/or insertions resulting from DNA replication errors… (More)
DOI: 10.1101/gr.127738.111

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Cite this paper

@article{Casola2012InterlocusGC, title={Interlocus gene conversion events introduce deleterious mutations into at least 1% of human genes associated with inherited disease.}, author={Claudio Casola and Ugne Zekonyte and Andrew D. Phillips and David N. Cooper and Matthew W. Hahn}, journal={Genome research}, year={2012}, volume={22 3}, pages={429-35} }