Interleukins adapt to parasites

1210 JEM Vol. 206, No. 6, 2009 TLR choreography Pathogen-sensing Toll-like receptors (TLRs) must be deployed accurately. Here, Fukui et al. show how finely tuned these receptors are. Tweaking a single amino acid in a TLR-trafficking molecule determined whether the signal was green or red for nucleic acid–sensing TLRs (page 1339). TLR7 and TLR9 recognize… CONTINUE READING