Interleukins 4 and 5 control expression of IL-2 receptor on murine B cells through independent induction of its two chains

@article{Loughnan1989Interleukins4A,
  title={Interleukins 4 and 5 control expression of IL-2 receptor on murine B cells through independent induction of its two chains},
  author={Michael S. Loughnan and Gustav J. V. Nossal},
  journal={Nature},
  year={1989},
  volume={340},
  pages={76-79}
}
RESTING B cells express few, if any, receptors for interleukin-2 (IL-2), whereas activated B cells can express receptors for and respond to IL-2 (refs 1, 2). IL-2 receptors can exist on the cell surface in three different forms; the complete high-affinity receptor, a heterodimer consisting of a chain of relative molecular mass (Mr) 70–75,000 (70–75K) and a chain of Mr 55K; the 70–75K chain alone, with intermediate affinity for IL-2; or the 55K chain alone, with low affinity for IL-2 (ref. 3… CONTINUE READING

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