Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease.

@article{Bendre2003Interleukin8SO,
  title={Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease.},
  author={M. Bendre and Donna C Montague and Terry S Peery and Nisreen S. Akel and Dana Gaddy and Larry J. Suva},
  journal={Bone},
  year={2003},
  volume={33 1},
  pages={28-37}
}
Interleukin 8 (IL-8) is a member of the alpha chemokine family of cytokines originally identified as a neutrophil chemoattractant. Recently, we reported that elevated levels of IL-8, but not parathyroid hormone-related protein (PTHrP), correlated with increased bone metastasis in a population of human breast cancer cells. We hypothesized that IL-8 expression by breast cancer cells would either indirectly influence osteoclastogenesis via nearby stromal cells or directly influence osteoclast… CONTINUE READING

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