Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells.

@article{Macmanus2007Interleukin8SP,
  title={Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells.},
  author={Christopher F Macmanus and Johanna Pettigrew and Angela Seaton and Catherine Wilson and P Johnstone Maxwell and Silvia Berlingeri and Colin Purcell and Maryalice McGurk and Patrick Gerard Johnston and David J. J. Waugh},
  journal={Molecular cancer research : MCR},
  year={2007},
  volume={5 7},
  pages={737-48}
}
We have shown previously that interleukin-8 (IL-8) and IL-8 receptor expression is elevated in tumor cells of human prostate biopsy tissue and correlates with increased cyclin D1 expression. Using PC3 and DU145 cell lines, we sought to determine whether IL-8 signaling regulated cyclin D1 expression in androgen-independent prostate cancer (AIPC) cells and to characterize the signaling pathways underpinning this response and that of IL-8-promoted proliferation. Administration of recombinant human… CONTINUE READING
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