Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation.

@article{Seaton2008Interleukin8SP,
  title={Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation.},
  author={Angela Seaton and Paula Scullin and P Johnstone Maxwell and Catherine P. Wilson and Johanna Pettigrew and Rebecca Gallagher and J. M. O'Sullivan and Patrick Gerard Johnston and David J. J. Waugh},
  journal={Carcinogenesis},
  year={2008},
  volume={29 6},
  pages={1148-56}
}
The aim of our study was to assess the importance of the CXC chemokine and interleukin (IL)-8 in promoting the transition of prostate cancer (CaP) to the androgen-independent state. Stimulation of the androgen-dependent cell lines, LNCaP and 22Rv1, with exogenous recombinant human interleukin-8 (rh-IL-8) increased androgen receptor (AR) gene expression at the messenger RNA (mRNA) and protein level, assessed by quantitative polymerase chain reaction and immunoblotting, respectively. Using an… CONTINUE READING

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