Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation.

  title={Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation.},
  author={Marc E de Perrot and Yasuo Sekine and Stefan Fischer and Thomas K Waddell and K Mcrae and Mingyao Liu and Dennis A. Wigle and Shaf H Keshavjee},
  journal={American journal of respiratory and critical care medicine},
  volume={165 2},
Cytokines have been shown to play an important role in promoting inflammation in the setting of ischemia-reperfusion injury. However, their role in human lung transplantation has not been systematically explored. This study was undertaken to examine the kinetics of cytokine release in 18 consecutive human lung transplantation procedures and to examine the relationships between their levels and donor factors, length of ischemic time, and allograft function. TNF-alpha, IFN-gamma, IL-10, IL-12… CONTINUE READING


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