Interleukin-8 expression in human nasal polyps.

  title={Interleukin-8 expression in human nasal polyps.},
  author={Jennifer S. Allen and R J Eisma and Gerald Leonard and Denis C Lafreniere and Donald L. Kreutzer},
  journal={Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery},
  volume={117 5},
The cytokine interleukin 8 (IL-8) has been shown to be a potent mediator of leukocyte recruitment and neovascularization in inflammatory and neoplastic diseases. In this study we hypothesize that IL-8 produced in the nasal polyp microenvironment is responsible for the leukocyte recruitment seen in nasal polyposis. To test this hypothesis we evaluated nasal polyps for distribution and content of IL-8 antigen with immunohistochemical techniques and radioimmunoassay to determine tissue levels of… CONTINUE READING

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