Interleukin-8 expression and modulation in human preovulatory follicles and ovarian cells.

@article{Arici1996Interleukin8EA,
  title={Interleukin-8 expression and modulation in human preovulatory follicles and ovarian cells.},
  author={Aydin Arici and Engin Oral and Orhan Bukulmez and S Buradagunta and Oner Engin and David L. Olive},
  journal={Endocrinology},
  year={1996},
  volume={137 9},
  pages={
          3762-9
        }
}
Just before the time of ovulation, the number of neutrophils increases markedly in the thecal layer of the leading follicle. A preovulatory rise in chemotactic activity for neutrophils in human follicular fluid has also been detected. We hypothesized that interleukin-8 (IL-8), a neutrophil chemoattractant/activating factor and a potent angiogenic agent, may be an important modulator of leukocyte chemotaxis in ovulatory function. In this regard we investigated the expression and modulation of IL… CONTINUE READING
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