Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis.

@article{Sansonetti1999Interleukin8CB,
  title={Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis.},
  author={Philippe J Sansonetti and J Arondel and Michel Ren{\'e} Huerre and Akihisa Harada and Kouji Matsushima},
  journal={Infection and immunity},
  year={1999},
  volume={67 3},
  pages={1471-80}
}
In shigellosis, the network of cellular interactions mediated by a balance of pro- and anti-inflammatory cytokines or chemokines is clearly tipped toward acute destructive inflammation of intestinal tissues by the bacterial invader. This work has addressed the role played by interleukin-8 (IL-8) in a rabbit model of intestinal invasion by Shigella flexneri. IL-8, which is largely produced by the epithelial cells themselves, appears to be a major mediator of the recruitment of polymorphonuclear… CONTINUE READING

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