Interleukin-8 as a macrophage-derived mediator of angiogenesis.

@article{Koch1992Interleukin8AA,
  title={Interleukin-8 as a macrophage-derived mediator of angiogenesis.},
  author={Alisa Erika Koch and Peter J. Polverini and Steven L. Kunkel and Lisa A Harlow and Luisa A DiPietro and Victor M. Elner and Susan G. Elner and Robert M. Strieter},
  journal={Science},
  year={1992},
  volume={258 5089},
  pages={1798-801}
}
Angiogenic factors produced by monocytes-macrophages are involved in the pathogenesis of chronic inflammatory disorders characterized by persistent angiogenesis. The possibility was tested that interleukin-8 (IL-8), which is a cytokine that is chemotactic for lymphocytes and neutrophils, is also angiogenic. Human recombinant IL-8 was potently angiogenic when implanted in the rat cornea and induced proliferation and chemotaxis of human umbilical vein endothelial cells. Angiogenic activity… CONTINUE READING
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