Interleukin-8 as a macrophage-derived mediator of angiogenesis.

  title={Interleukin-8 as a macrophage-derived mediator of angiogenesis.},
  author={Alisa Erika Koch and Peter J. Polverini and Steven L. Kunkel and Lisa A Harlow and Luisa A DiPietro and Victor M. Elner and Susan G. Elner and Robert M. Strieter},
  volume={258 5089},
Angiogenic factors produced by monocytes-macrophages are involved in the pathogenesis of chronic inflammatory disorders characterized by persistent angiogenesis. The possibility was tested that interleukin-8 (IL-8), which is a cytokine that is chemotactic for lymphocytes and neutrophils, is also angiogenic. Human recombinant IL-8 was potently angiogenic when implanted in the rat cornea and induced proliferation and chemotaxis of human umbilical vein endothelial cells. Angiogenic activity… CONTINUE READING
Highly Influential
This paper has highly influenced 21 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
683 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 683 extracted citations

Similar Papers

Loading similar papers…