Interleukin-8 and the chemokine family.

  title={Interleukin-8 and the chemokine family.},
  author={Marco Baggiolini and Pius Loetscher and Bernhard Moser},
  journal={International journal of immunopharmacology},
  volume={17 2},
Two subfamilies of chemokines are distinguished depending on the arrangement of the first two of four conserved cysteines, which are either separated by one amino acid (CXC chemokines) or adjacent (CC chemokines). IL-8 and the other CXC chemokines act preferentially on neutrophils, while the CC chemokines (MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta) act on monocytes, but not neutrophils, and have additional activities toward basophil and eosinophil granulocytes, and T-lymphocytes… CONTINUE READING