Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis

@inproceedings{Lee2012Interleukin8AI,
  title={Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis},
  author={Young Soo Lee and Inkyum Choi and Yan Ning and Nam Youl Kim and Vicken Khatchadourian and Dongyun Yang and Hong Keun Chung and D Choi and Melissa Janae Labonte and Robert D. Ladner and Kalyan C Nagulapalli Venkata and David O. Rosenberg and Nicos A Petasis and Heinz-Josef Lenz and Y-K Hong},
  booktitle={British Journal of Cancer},
  year={2012}
}
Background:Colorectal cancer (CRC) is a leading cause of death in the United States. Increased level of interleukin-8 (IL-8) and CXCR2 on tumours and in the tumour microenvironment has been associated with CRC growth, progression and recurrence in patients. Here, we aimed to evaluate the effects of tissue microenvironment-encoded IL-8 and CXCR2 on colon cancer progression and metastasis.Methods:A novel immunodeficient, skin-specific IL-8-expressing transgenic model was generated to evaluate… CONTINUE READING
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