Interleukin 7 receptor mediates the activation of phosphatidylinositol-3 kinase in human B-cell precursors.

@article{Dadi1993Interleukin7R,
  title={Interleukin 7 receptor mediates the activation of phosphatidylinositol-3 kinase in human B-cell precursors.},
  author={Harjit K Dadi and Sui Ke and Chaim M. Roifman},
  journal={Biochemical and biophysical research communications},
  year={1993},
  volume={192 2},
  pages={459-64}
}
Interleukin 7 appears to be central to promoting growth and differentiation of lymphocyte precursors. Pro-B cells, as well as pre-pre-B cells, but not mature cells express the IL-7 receptor suggesting an important role for IL-7 during these early stages of B cell maturation. Indeed, IL-7 was shown to promote not only growth but also immunoglobulin gene rearrangement in these cells. However, the mechanism by which IL-7 receptor transduces these growth signals remains elusive. In an attempt to… CONTINUE READING

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