Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

@article{Gregory2007Interleukin7R,
  title={Interleukin 7 receptor $\alpha$ chain ( IL7R ) shows allelic and functional association with multiple sclerosis},
  author={S. Gregory and S. Schmidt and P. Seth and J. Oksenberg and J. Hart and A. Prokop and S. Caillier and M. Ban and A. Goris and L. Barcellos and R. Lincoln and J. McCauley and S. Sawcer and D. Compston and B. Dubois and S. Hauser and M. Garcia-Blanco and M. Pericak-Vance},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={1083-1091}
}
Multiple sclerosis is a demyelinating neurodegenerative disease with a strong genetic component. Previous genetic risk studies have failed to identify consistently linked regions or genes outside of the major histocompatibility complex on chromosome 6p. We describe allelic association of a polymorphism in the gene encoding the interleukin 7 receptor α chain ( IL7R ) as a significant risk factor for multiple sclerosis in four independent family-based or case-control data sets (overall P = 2.9… Expand
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Interleukin 7 receptor alpha chain haplotypes vary in their influence on multiple sclerosis susceptibility and response to interferon Beta.
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