Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression.

@article{Shindo2015Interleukin7AA,
  title={Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression.},
  author={Yuichiro Shindo and Jacqueline Unsinger and Charles R. Burnham and Jonathan Green and Richard S Hotchkiss},
  journal={Shock},
  year={2015},
  volume={43 4},
  pages={
          334-43
        }
}
Sepsis remains a major cause of morbidity and mortality in most intensive care units. Protracted sepsis can evolve into a state of profound immunosuppression characterized by secondary infections, frequently with opportunistic-type pathogens. Immunoadjuvant therapy is currently being evaluated as a novel treatment for patients with sepsis. Two of the most promising immunoadjuvants are interleukin-7 (IL-7) and anti-programmed cell death 1 antibody (anti-PD-1). Both IL-7 and anti-PD-1 have been… CONTINUE READING
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