Interleukin-7 activates human naive CD4+ cells and primes for interleukin-4 production.

@article{Webb1997Interleukin7AH,
  title={Interleukin-7 activates human naive CD4+ cells and primes for interleukin-4 production.},
  author={Louise M C Webb and Brian M. J. Foxwell and Marc Feldmann},
  journal={European journal of immunology},
  year={1997},
  volume={27 3},
  pages={633-40}
}
Interleukin (IL)-4 is considered to be essential for T helper (Th)2 cell development, yet in areas of primary T cell activation, CD4+ cells are its only source. This implies that other signals must drive the initial expression of IL-4 production. The role of CD28 co-stimulation in Th2 subset development has been described. However, in mice deficient for CD28, Th2 responses are diminished, but not abrogated. Cytokines produced within the lymphoid tissue, e.g. IL-7, may be important in the… CONTINUE READING