Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.

@article{Kasten2010Interleukin7T,
  title={Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.},
  author={Kevin Richard Kasten and Priya S. Prakash and Jacqueline Unsinger and Holly S. Goetzman and Lisa G. England and Cindy M. Cave and Aaron P. Seitz and Cristina N. Mazuski and Tony T. Zhou and Michel Morre and Richard S Hotchkiss and David A Hildeman and Charles C Caldwell},
  journal={Infection and immunity},
  year={2010},
  volume={78 11},
  pages={
          4714-22
        }
}
The sepsis syndrome represents an improper immune response to infection and is associated with unacceptably high rates of mortality and morbidity. The interactions between T cells and the innate immune system while combating sepsis are poorly understood. In this report, we observed that treatment with the potent, antiapoptotic cytokine interleukin-7 (IL-7) accelerated neutrophil recruitment and improved bacterial clearance. We first determined that T cells were necessary for the previously… CONTINUE READING

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