Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

@article{Taga1989Interleukin6TT,
  title={Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130},
  author={Tetsuya Taga and Masahiko Hibi and Y. Hirata and Katsuhiko Yamasaki and Kiyoshi Yasukawa and Tadashi Matsuda and Toshio Hirano and Tadamitsu Kishimoto},
  journal={Cell},
  year={1989},
  volume={58},
  pages={573-581}
}
The soluble interleukin-6 receptor and related proteins.
  • S. Rose-John
  • Biology
    Best practice & research. Clinical endocrinology & metabolism
  • 2015
Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes.
TLDR
There is a substantial difference in the mechanism of receptor engagement by cytokines that signal via gp130, suggesting a common mode of recognition of helical cytokines by class I cytokine receptors.
Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses.
TLDR
SIL-6R of human plasma must be regarded as an antagonistic molecule that enhances the inhibitory activity of sgp130, a promising candidate for the development of IL-6 antagonists.
IL-6 Receptor Independent Stimulation of Human gp130 by Viral IL-61
TLDR
It is demonstrated that purified recombinant vIL-6 is the first cytokine which directly binds and activates gp130, and points to a possible role of this viral cytokine in the pathophysiology of human herpes virus 8.
IL-6 receptor and mechanism of signal transduction.
The Immunoglobulin-like Module of gp130 Is Required for Signaling by Interleukin-6, but Not by Leukemia Inhibitory Factor*
TLDR
It is shown that signaling by IL-6, but not LIF, is significantly reduced by mutations in the Ig-like module of gp130, and the binding of125I-labeled IL- 6 or LIF is not affected by these mutations.
Identification of a regulatory domain of the interleukin-6 receptor.
Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily
TLDR
In this report, the isolation and functional expression of a human IL-4-R cDNA is described, which encodes a protein that binds humanIL-4 with high affinity and can confer responsiveness to human Il-4.
Interleukin 6 and its receptor: ten years later.
  • T. Hirano
  • Biology
    International reviews of immunology
  • 1998
TLDR
JAK tyrosine kinase is a key molecule that can initiate multiple signal-transduction pathways by inducing the tyrosinesine-phosphorylation of the cytokine receptor, gp130 in the case of IL-6, on which several signaling molecules are recruited, including STAT, a signal transducer and activator of transcription, and SHP-2, which links to the Ras-MAP kinase pathway.
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