Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

  title={Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130},
  author={T. Taga and M. Hibi and Yuuichi Hirata and K. Yamasaki and T. Kishimoto},
  • T. Taga, M. Hibi, +2 authors T. Kishimoto
  • Published 1989
  • Biology, Medicine
  • Cell
  • Interleukin-6 mediates pleiotropic functions in various types of cells through its specific receptor (IL-6-R), the cDNA of which has already been cloned. We report here that an 80 kd single polypeptide chain (IL-6-R) is involved in IL-6 binding and that IL-6 triggers the association of this receptor with a non-ligand-binding membrane glycoprotein, gp130. The association takes place at 37 degrees C within 5 min and is stable for at least 40 min in the presence of IL-6, but does not occur at 0… CONTINUE READING
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