Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: the role for KDR and MMP-9.

@article{Yao2006Interleukin6TH,
  title={Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: the role for KDR and MMP-9.},
  author={Jianhua S. Yao and Wenwu Zhai and William Lee Young and Guo-Yuan Yang},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={342 4},
  pages={
          1396-404
        }
}
Interleukin-6 (IL-6) is involved in angiogenesis. However, the underlying mechanisms are unknown. Using human cerebral endothelial cell (HCEC), we report for the first time that IL-6 triggers HCEC proliferation and migration in a dose-dependent manner, specifically associated with enhancement of VEGF expression, up-regulated and phosphorylated VEGF receptor-2 (KDR), and stimulated MMP-9 secretion. We investigated the signal pathway of IL-6/IL-6R responsible for KDR's regulation. Pharmacological… CONTINUE READING
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