Interleukin-6 stimulates c-myc expression and proliferation of cultured vascular smooth muscle cells.

@article{Nabata1990Interleukin6SC,
  title={Interleukin-6 stimulates c-myc expression and proliferation of cultured vascular smooth muscle cells.},
  author={Toshiya Nabata and Shin-ichiro Morimoto and Eitetsu Koh and Takahiro Shiraishi and Takeshi Ogihara},
  journal={Biochemistry international},
  year={1990},
  volume={20 3},
  pages={
          445-53
        }
}
The effects of interleukin-6 (IL-6), a cytokine recently found to be secreted by monocytes and macrophages, on c-myc expression and proliferation of cultured vascular smooth muscle cells (VSMC) were investigated. Treatment with IL-6 caused rapid increase in the c-myc mRNA level of VSMC. It also stimulated DNA synthesis and proliferation of the cells significantly and dose-dependently at concentrations of more than 10 U/ml. These results suggest that IL-6 may be important in the proliferation of… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS, ESTIMATED 34% COVERAGE

120 Citations

0510'90'96'03'10'17
Citations per Year
Semantic Scholar estimates that this publication has 120 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…