Interleukin-6 signaling pathway in targeted therapy for cancer.

  title={Interleukin-6 signaling pathway in targeted therapy for cancer.},
  author={Yuqi Guo and Feng Xu and Tianjian Lu and Zhenfeng Duan and Zhan Zhang},
  journal={Cancer treatment reviews},
  volume={38 7},
Interleukin-6 (IL-6) is a multifunctional cytokine which plays an important role in a wide range of biologic activities in different types of cell including tumor cells. IL-6 is involved in the host immune defense mechanism as well as the modulation of growth and differentiation in various malignancies. These effects are mediated by several signaling pathways, in particular the signal transducer and transcription activator 3 (Stat3). There exists abundant evidence demonstrating that deregulated… CONTINUE READING
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