Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

@inproceedings{Sarwar2012Interleukin6RP,
  title={Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies},
  author={Nadeem Sarwar and Adam S. Butterworth and Daniel F. Freitag and J. Paige Gregson and Peter Willeit and Donal Gorman and Pei Gao and Danish Saleheen and Augusto Rendon and Christopher P. Nelson and Peter Stuart Braund and Alistair Scott Hall and Daniel I. Chasman and Georg Schett and John Campbell Chambers and Emelia J Benjamin and Paul W Franks and Robert Clarke and Arthur A. M. Wilde and Mieke D. Trip and Maristella Steri and Jacqueline C. M. Witteman and Lu Qi and C. Ellen van der Schoot and Ulf de Faire and Jeanette Erdmann and Heather M Stringham and C Jeremiah Crespo and Daniel J. Rader and David Melzer and David Reich and Bruce Mark Psaty and Marcus E. Kleber and Demosthenes B. Panagiotakos and Johann Willeit and Patrik Wennberg and Mark Woodward and Svetlana Adamovi{\'c} and Eric B Rimm and Tom W. Meade and Richard F Gillum and Jonathan A. Shaffer and Albert Hofman and Altan Onat and Johan Sundstr{\"o}m and Sylvia Wassertheil-Smoller and Dan Mellstr{\"o}m and John Gallacher and Mary Cushman and Russell P Tracy and Jussi Kauhanen and Magnus Karlsson and J Ukka T. Salonen and L. W. Wilhelmsen and Philippe Amouyel and Bernard Cantin and Gunnar Sigurdsson and Matthew Fisher and JoAnn E. Manson and George Davey-Smith and Paul I W de Bakker and Christopher J. O'Donnell and James F Wilson and Anthony Gerard Wilson and Themistocles L. Assimes and J O Jansson and C Ohlsson and {\AA}sa Tivesten and {\"O}sten Ljunggren and Muredach P. Reilly and Anders Hamsten and Erik Ingelsson and François Cambien and Joseph Hung and G Neil Thomas and Michael Boehnke and Heribert Schunkert and Folkert W. Asselbergs and John J. P. Kastelein and Vilmundur Gudnason and Veikko Salomaa and Tamara B. Harris and Jaspal Singh Kooner and Kristine H Allin and B{\o}rge G. Nordestgaard and Jemma C Hopewell and Alison Helena Goodall and Paul M. Ridker and Hilma H{\'o}lm and Hugh Watkins and Willem H Ouwehand and Nilesh J. Samani and Stephen Kaptoge and Emanuele Di Angelantonio and Olivier Harari and John Danesh},
  booktitle={The Lancet},
  year={2012}
}
BACKGROUND Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling. METHODS In a collaborative meta-analysis, we studied Asp358Ala (rs2228145) in IL6R in relation to a panel of conventional risk… CONTINUE READING
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