Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization.

@article{IzumiNagai2007Interleukin6RA,
  title={Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization.},
  author={Kanako Izumi-Nagai and Norihiro Nagai and Yoko Ozawa and Masahiko Mihara and Yoshiyuki Ohsugi and Toshihide Kurihara and Takashi Koto and Shingo Satofuka and Makoto Inoue and Kazuo Tsubota and Hideyuki Okano and Yuichi Oike and Susumu Ishida},
  journal={The American journal of pathology},
  year={2007},
  volume={170 6},
  pages={2149-58}
}
Interleukin (IL)-6, a potent proinflammatory cytokine, is suggested to be a risk factor for choroidal neovascularization (CNV) because of its increased levels in the serum of patients with age-related macular degeneration; however, the role of IL-6 in CNV has not been defined. The present study reveals the critical contribution of IL-6 signaling and its downstream STAT3 pathway to the murine model of laser-induced CNV. CNV induction by laser treatment stimulated IL-6 expression in the retinal… CONTINUE READING

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