Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. Women.

@article{Qi2007Interleukin6RG,
  title={Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. Women.},
  author={Lu Qi and N M El Rifai and Frank B Hu},
  journal={Diabetes},
  year={2007},
  volume={56 12},
  pages={3075-81}
}
OBJECTIVE To examine the associations between common variations in the IL6R gene and circulating interleukin (IL)-6 levels and diabetes risk. RESEARCH DESIGN AND METHODS We determined 10 linkage disequilibrium (LD)-tagging single nucleotide polymorphisms (SNPs) (SNP1 to SNP10) for the IL6R gene in a nested case-control study of 672 diabetic and 1,058 healthy European Caucasian women (IL-6 levels were measured in a subgroup of 1,348 women). RESULTS In both control and diabetic patients… CONTINUE READING
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