Interleukin-6 promoter polymorphisms (-174 G/C) in Malaysian patients with systemic lupus erythematosus.

  title={Interleukin-6 promoter polymorphisms (-174 G/C) in Malaysian patients with systemic lupus erythematosus.},
  author={Kek Heng Chua and Boon Pin Kee and Serena Y Tan and L. H. Lian},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  volume={42 6},
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that involves the inflammation of various organs upon deposition of immune complexes and is characterized by uncontrolled B cell hyperactivity. Despite intensive research on the etiology of the disease, the exact cause of the onset of SLE is unknown. The pathogenesis of the disease has been proposed to be associated with the imbalance of T helper type 1 (Th1) and Th2 cytokine activities. Elevated serum levels of interleukin-6… CONTINUE READING
25 Citations
23 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 25 extracted citations


Publications referenced by this paper.
Showing 1-10 of 23 references

Systemic lupus erythematosus: From disease pathogenesis to therapy

  • CG Katsiari, GC Tsokos
  • Drug Discov Today Dis Mech 2006;
  • 2006
1 Excerpt

Similar Papers

Loading similar papers…