Interleukin-6 promoter polymorphism (--174 G/C) in Caucasian German patients with systemic lupus erythematosus.

@article{Schotte2001Interleukin6PP,
  title={Interleukin-6 promoter polymorphism (--174 G/C) in Caucasian German patients with systemic lupus erythematosus.},
  author={Heiko Schotte and Bernhard Schl{\"u}ter and Stephan Rust and Gunter Assmann and Wolfram Domschke and Markus Gaubitz},
  journal={Rheumatology},
  year={2001},
  volume={40 4},
  pages={393-400}
}
BACKGROUND A biallelic polymorphism (--174 G/C) within the interleukin-6 (IL-6) promoter reportedly has functional importance through the modulation of IL-6 expression in vitro and in vivo. METHODS We performed a population-based case-control study to analyse the association of the --174 G/C polymorphism with disease susceptibility and clinical manifestations in 211 German patients with systemic lupus erythematosus (SLE). RESULTS There were no significant differences in allelic and… CONTINUE READING

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