Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency mice.

@article{Katsume1997Interleukin6OC,
  title={Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency mice.},
  author={Asao Katsume and Takashi Miyai and Hisanori Suzuki and Yasutaka Moriguchi and Hiroko Kawata and Tomohide Tatsumi and Sachiko Suematsu and Tadamitsu Kishimoto and Yoshiyuki Ohsugi},
  journal={Clinical immunology and immunopathology},
  year={1997},
  volume={82 2},
  pages={117-24}
}
C57BL/6 human interleukin-6 (IL-6) transgenic mice develop mesangial proliferative glomerulonephritis with massive IgG1 plasmacytosis and die of renal failure in early life. To test whether the IL-6 overexpression could cause development of mesangial proliferative glomerulonephritis without plasmacytosis or promote proliferation of immature B cells that have not undergone immunoglobulin gene rearrangement, the IL-6 transgene was introduced into mice with severe combined immunodeficiency (SCID… CONTINUE READING
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