Interleukin-6 modulates hepatic and muscle protein synthesis during hemodialysis.

@article{Raj2008Interleukin6MH,
  title={Interleukin-6 modulates hepatic and muscle protein synthesis during hemodialysis.},
  author={Dominic S. C. Raj and Pope L. Moseley and Elizabeth A. Dominic and Aideloje Onime and Antonios H Tzamaloukas and Adele Boyd and Vallabh O. Shah and Robert S. Glew and Robert H. Wolfe and A Francisco Ferrando},
  journal={Kidney international},
  year={2008},
  volume={73 9},
  pages={
          1054-61
        }
}
Increased demand for amino acids to sustain acute-phase protein synthesis could be the stimulus for the increased muscle protein catabolism during hemodialysis (HD). This could be attenuated by intradialytic amino-acid infusion. To test this, we measured the fractional synthesis rates of albumin, fibrinogen, and muscle protein in eight patients with end-stage renal disease at baseline before dialysis and during HD without or with amino-acid infusion. The percentage change in the fractional… CONTINUE READING
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